Amlodipine gingival overgrowth: alternatives and management
Amlodipine, a calcium-channel blocker, is associated with drug-induced gingival hyperplasia. CureusManagement includes using the lowest effective dose, meticulous oral hygiene, consideration of drug substitution, and gingivectomy when enlargement has not reversed after three to six months following drug discontinuation. Cureus
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1The Oral Cavity as a Window to Systemic Disease: Diagnostic Clues and Pre-treatment Dental Management for Interdisciplinary TraineesSarbeland L, Sultani MY, Afzalzada N, et al. · Cureus · 2026Narrative review
Review
Drug-induced gingival hyperplasia has been associated with several medication classes, including calcium channel blockers (particularly nifedipine and amlodipine), cyclosporine, and anticonvulsants (phenytoin and carbamazepine) [16,48]. Management includes prescribing the lowest effective dose, promoting meticulous oral hygiene, considering drug substitution, and surgical excision (gingivectomy) if not reversed after three to six months of drug discontinuation [48]. Oral mucositis is commonly associated with chemotherapeutic agents (particularly 5-fluorouracil, methotrexate, and doxorubicin), targeted therapies (such as mTOR inhibitors and everolimus), and radiation therapy. Mucositis affects up to 40% of patients receiving standard-dose chemotherapy and up to 80% of patients receiving high-dose chemotherapy or head and neck radiation (Table 8) [52].
What this supports
- Amlodipine, a calcium-channel blocker, is associated with drug-induced gingival hyperplasia.
- Management includes using the lowest effective dose, meticulous oral hygiene, consideration of drug substitution, and gingivectomy when enlargement has not reversed after three to six months following drug discontinuation.
The Oral Cavity as a Window to Systemic Disease: Diagnostic Clues and Pre-treatment Dental Management for Interdisciplinary Trainees. Copyright © 2026, Sarbeland et al. Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/).
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